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Dose-response relationship between reach repetition and indicators of inflammation and movement dysfunction in a rat model of work-related musculoskeletal disorder.
Barr-AE; Amin-M; Barbe-MF
Proceedings of the Human Factors and Ergonomics Society 46th Annual Meeting, September 29 - October 4, 2002, Baltimore, Maryland, Bringing Fundamentals & New Opportunities. Santa Monica, CA: Human Factors and Ergonomics Society, 2002 Sep; 46(Med Sys Rehab):1486-1490
The purpose of this study was to compare the effects of a high or low repetition reaching and grasping task on serum levels of interleukin-1alpha. (lL-1alpha.) and IL-1beta and on reach performance in a rat model of work-related musculoskeletal disorder (MSD). Forty-seven rats reached repetitively for 2 hours/day, 3 days/week for 6-8 weeks at a high or low rate. Reach rate and abnormal movement patterns were recorded. Serum was collected at 6 and 8 weeks for ELISA assay of IL-1alpha. and IL-1beta. High repetition animals experienced a 2-fold decline in reach rate, strong emergence of a raking movement, and increased IL-1alpha. IL-1alpha decreased in the low repetition group. IL-1beta decreased in both groups. This model provides evidence that inflammation increases with repetition. At the higher reach rate, persistent IL-1alpha serum levels indicate chronic inflammation that is attenuated at the lower reach rate. These findings support the use of risk reduction in MSD prevention.
Animal-studies; Laboratory-animals; Muscular-disorders; Musculoskeletal-system-disorders; Muscle-tissue; Muscle-function; Repetitive-work; Ergonomics
Issue of Publication
Med Sys Rehab
Proceedings of the Human Factors and Ergonomics Society 46th Annual Meeting, September 29 - October 4, 2002, Baltimore, Maryland, Bringing Fundamentals & New Opportunities
Page last reviewed: September 2, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division