Use of dermal LD50 as a criterion for skin notation (letter to the editor).
Chen-CP; Boeniger-MF; Ahlers-HW
Appl Occup Environ Hyg 2003 Mar; 18(3):154-155
We read with interest the recent article by Czerczak and Kupczewska entitled "Assignment of Skin Notation for Maximum Allowable Concentration (MAC) List in Poland" in the March 2002 issue of Applied Occupational and Environmental Hygiene. Czerczak and Kupczewska analyzed the organic chemicals from the Polish MAC list for skin notation (the Sk index) and concluded that ". . . the dermal dose LD50s [lethal dose 50 percent] determined on experimental animals ought to be adopted as the fundamental criterion for providing a substance with the percutaneous absorption notation in the MAC list." We would like to comment on the need for a careful analysis of the data underlying a dermal LD50 or an occupational exposure limit (OEL) before using either of them to assess the appropriateness of a dermal hazard notation.
Lethal-dose; Dose-response; Skin-absorption; Chemical-properties; Occupational-exposure; Exposure-levels; Exposure-limits; Toxic-effects; Skin-exposure; Information-systems; Animal-studies; Decision-making; Analytical-processes; Dermal-exposure; Dermal-absorption
333-41-5; 107-07-3; 298-00-0; 563-12-2; 298-02-2; 106-87-6
Disease and Injury: Allergic and Irritant Dermatitis
Applied Occupational and Environmental Hygiene