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Development of colorimetric indicators: a new technique to determine glutaraldehyde and alkaline glutaraldehyde contamination.
International conference on occupational and environmental exposures of skin to chemicals: science and policy, September 8-11, 2002, Washington, DC. Morgantown, WV: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 2002 Sep; :165
The aim of the study was to develop a new indicator sensor pad for detection of glutaraldehyde permeation of chemical protective gloves. The pad carries a reagent which responds to glutaraldehyde contaminant by producing a color change. Some commonly used glutaraldehyde and alkaline glutaraldehyde solutions, Metricide, Cetylcide-G, and 50% glutaraldehyde solution, were analyzed by solvent desorption and gas chromatography. All glutaraldehyde solutions exhibited >98% adsorption on the pads over the spiking range 0.05-5.0 µL. Recovery for each glutaraldehyde solution was calculated, ranging from 58-92% (RSD =4.0%) for all glutaraldehyde solutions. Breakthrough times for two protective glove materials (PVC and polymerized alkene) were determined using the Thermo-Hand Method, and found to range from 76 to 150 min for Metricide, from 170 to 230 min for Cetylcide-G, and from 232 to 300 min for 50% glutaraldehyde. The quantitative mass of the glutaraldehyde solutions on the pads at the time of breakthrough detection ranged from 35-37, 37-39, and 38-40 µg/cm² for Metricide, Cetylcide-G, and 50% glutaraldehyde, respectively. The new aldehyde indicator pad should find utility in detecting, collecting, and quantitative analyzing glutaraldehyde and alkaline glutaraldehyde permeation samples in the workplace.
Gloves; Protective-clothing; Protective-equipment; Personal-protection; Personal-protective-equipment; Solvents; Gas-chromatography; Quantitative-analysis
Disease and Injury: Allergic and Irritant Dermatitis; Research Tools and Approaches: Control Technology and Personal Protective Equipment
International conference on occupational and environmental exposures of skin to chemicals: science and policy, September 8-11, 2002, Washington, DC
PA; VA; DC
Page last reviewed: September 2, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division