Parental atopy and asthma in rural children: is there a link?
Svendsen-ER; Naleway-AL; Thorne-PS; Stromquist-AM; Merchant-JA
Am J Respir Crit Care Med 2003 Apr; 167(7):A853
Recent literature has reported low asthma and/or atopy prevalence in rural/farm populations. We found relatively high rates of childhood asthma (16%) and atopy (36%) in a completely rural cohort. The highest prevalence of asthma was in farm children, atopy in rural town children. We tested the hypothesis that parental farm allergies were associated with these outcomes in a cross-sectional study of data from Round I of the Keokuk County Rural Health Study. Parental interview, spirometry, methylcholine inhalation challenge, skin-prick testing, and serum specific IgE (sub-sample only) data were included. This study was limited to 487 children ages 3-17 years. Several specific parental allergy and sensitization variables were associated with asthma or atopy, including farm allergies to hogs (31.0% prev., asthma OR= 1.98, 95%CI 1.21-3.24), soybeans (16.6% prev., asthma OR= 2.48, 95%CI 1.42-4.34), and chickens (8.2% prev., atopy OR= 1.90, 95%CI 0.993.63). After adjustment for other covariates, multiple comparisons within homes, and other environmental exposures; parental allergy to soybeans was associated with increased asthma prevalence in children (OR= 1.12, 95%CI 1.02-1.23). Similarly, parental allergy to chicken was weakly associated with atopy (OR= 1.15, 95%CI 0.99-1.35). Our study suggests that atopy prevalence on farms was low relative to town and rural residents. Parental atopy to farm antigens was a weak contributor to a childs risk of developing atopic illnesses. This abstract does not necessarily represent EPA policy.
Bronchial-asthma; Farmers; Children; Allergies; Inhalation-studies; Spirometry; Environmental-exposure; Sensitization; Agricultural-workers; Agriculture; Pulmonary-system-disorders; Respiratory-system-disorders
Abstract; Conference/Symposia Proceedings
American Journal of Respiratory and Critical Care Medicine, 2003 International Conference, The American Thoracic Society, Seattle, WA, May 16-21, 2003
University of Iowa, Iowa City, Iowa