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Dietary potassium oxonate increases uric acid in rat plasma and bronchoalveolar lavage fluid.
Kain-B; Porter-D; Blemings-KP; Klandorf-H
FASEB J 2002 Mar; 16(5):A963
Uric acid (VA) may be an important antioxidant, but its role in the lung has not been investigated. It is our hypothesis that by raising VA concentrations, silica-induced pulmonary damage may be ameliorated. In the first of a two part study, 52 male Sprague-Daley rats were randomized to four dietary treatments of 0, 2.5, 5.0, or 7.5% potassium oxonate (PO), an inhibitor of uricase. Four rats per group were sacrificed on days 10, 20, and 30. Plasma and bronchoalveolar lavage (BAL) fluid were analyzed for UA by HPLC. Dietary PO increased plasma (p<O.O.5), and BAL fluid (p=0.006) VA concentrations approximately four fold. PO had no effect on growth rate, BAL albumin, lactate dehydrogenase, alveolar macrophage and polymorph nuclear leukocyte cell yields, or NO-dependant AM chemiluminescence's (p>0.0.5). The ability of dietary PO to increase VA levels, and its lack of non-specific toxicity, will be utilized in future studies designed to investigate the effect of increased VA levels on silica-induced pulmonary disease.
Antioxidants; Lung; Silicates; Pulmonary-system; Pulmonary-system-disorders; Pulmonary-function; Animal-studies; Laboratory-animals; Lung-disorders; Silica-dusts; Animals; Pulmonary-disorders
Abstract; Conference/Symposia Proceedings
Issue of Publication
The FASEB Journal, Experimental Biology 2002, New Orleans, Louisiana, April 20-24, 2002
Page last reviewed: May 5, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division