Arsenic carcinogenicity: relevance of c-Src activation.
Simeonova PP; Luster MI
Mol Cell Biochem 2002 May-Jun; 234-235(1-2):277-282
Environmental and occupational exposure to arsenic is associated with increased risk of skin, urinary bladder and respiratory tract cancers. Increasing evidence indicates that arsenic acts at the level of tumor promotion by modulating the signaling pathways responsible for cell growth. One of this pathways might include c-Src dependent EGFR and MAPK activation.
Arsenic-compounds; Carcinogenicity; Genes; Skin-cancer; Bladder-cancer; Occupational-exposure; Environmental-exposure; Respiratory-system-disorders; Tumors; Cell-growth; Liver; Kidneys;
Author Keywords: gene expression; reactive oxygen species; skin cancer; bladder cancer
P.P. Simeonova, NIOSH; HELD; TMBB, 1095 Willowdale Road, Mailstop 3014, Morgantown, WV 26505-2888, USA
Molecular and Cellular Biochemistry