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Arsenic carcinogenicity: relevance of c-Src activation.
Simeonova PP; Luster MI
Mol Cell Biochem 2002 May-Jun; 234-235(1-2):277-282
Environmental and occupational exposure to arsenic is associated with increased risk of skin, urinary bladder and respiratory tract cancers. Increasing evidence indicates that arsenic acts at the level of tumor promotion by modulating the signaling pathways responsible for cell growth. One of this pathways might include c-Src dependent EGFR and MAPK activation.
Arsenic-compounds; Carcinogenicity; Genes; Skin-cancer; Bladder-cancer; Occupational-exposure; Environmental-exposure; Respiratory-system-disorders; Tumors; Cell-growth; Liver; Kidneys
P.P. Simeonova, NIOSH; HELD; TMBB, 1095 Willowdale Road, Mailstop 3014, Morgantown, WV 26505-2888, USA
Issue of Publication
Molecular and Cellular Biochemistry
Page last reviewed: March 3, 2021
Content source: National Institute for Occupational Safety and Health Education and Information Division