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Exposure to asbestos and lung and pleural cancer mortality among pulp and paper industry workers.
Carel R; Boffetta P; Kauppinen T; Teschke K; Andersen A; Jappinen P; Pearce N; Rix BA; Bergeret A; Coggon D; Persson B; Szadkowska-Stanczyk I; Kielkowski D; Henneberger P; Kishi R; Facchini LA; Sala M; Colin D; Kogevinas M
J Occup Environ Med 2002 Jun; 44(6):579-584
We studied the mortality from lung and pleural cancers in a cohort of 62,937 male workers employed for at least 1 year in the pulp and paper industry in 13 countries during 1945 to 1996. Mill departments were classified according to probability and level of exposure to asbestos on the basis of available dust measurements and mill-specific information on exposure circumstances. Thirty-six percent of workers were classified as ever exposed to asbestos. Standardized mortality ratios of lung cancer were 0.99 (95% confidence interval [CI], 0.90 to 1.08) among unexposed and 1.00 (95% CI, 0.90 to 1.11) among ever exposed workers. The number of pleural cancer deaths among unexposed workers was 10; that among exposed workers was 14, most of which occurred among maintenance workers. In internal analyses, a trend in mortality from either neoplasm was suggested for estimated cumulative exposure to asbestos, weighted for the individual probability of exposure within the department and for duration of exposure (relative risk for lung cancer for 0.78+ f/cc-years, as compared with < or = 0.01 f/cc-years: 1.44; 95% CI, 0.85 to 2.45; corresponding relative risk for pleural cancer: 2.43; 95% CI, 0.43 to 13.63). Despite a possible nondifferential misclassification of exposure and outcome, this study suggests that the carcinogenic effect of asbestos can be detected among workers employed in industries such as the pulp and paper industry, in which it is not considered to be a major hazard.
Occupational-exposure; Exposure-levels; Asbestos-dust; Asbestos-fibers; Lung-cancer; Mortality-rates; Work-environment; Workers; Paper-manufacturing-industry; Pulp-industry; Dust-particles; Dusts; Particulate-dust; Particulates; Occupational-hazards; Health-hazards
Dr. Paolo Boffetta, Unit of Environmental Cancer Epidemiology, International Agency for Research on Cancer, 150 cours Albert-Thomas, 69008, Lyon, France
Issue of Publication
Disease and Injury: Asthma and Chronic Obstructive Pulmonary Disease; Research Tools and Approaches: Exposure Assessment Methods
Journal of Occupational and Environmental Medicine
Page last reviewed: September 2, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division