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Predictors of chronic beryllium disease and sensitization.
Rosenman KD; Rossman MD; Reily MJ; Bush A; Hertzberg V; Regovich J; Aronchick J; Parker J; Rice C
Am J Respir Crit Care Med 2002 Apr; 165(8)(Suppl):A48
A cohort of 1,464 current and former workers from two beryllium processing facilities in Eastern Pennsylvania were screened utilizing chest radiographs interpreted by a panel of three "B" readers, spirometry and blood beryllium lymphocyte proliferation testing (BLPT) to look at predictors of Chronic Beryllium Disease (CBD) and Beryllium Sensitization (BS). Individuals with radiographs which at least 2 of 3 "B" readers interpreted as showing changes consistent with pneumoconiosis and/or two positive BLPTs were referred for bronchoscopy with bronchial lavage and biopsy. Sixty (4.1%) individuals were diagnosed with definite or probable CBD, another 16 (1.1%) with possible CBD, 72 (4.9%) with BS and 10 (0.7%) with possible BS. Predictors examined included: facility A vs. facility B the OR = 1.5 (95% CI .9-2.7)for CBD and the OR = 1.3 (95% CI .8-2.2) for BS; female vs. male gender the OR = .9 (95% CI .4- 2.8) for CBD and the OR = 2.3 (95% CI 1.1-4.9) for BS; never vs. ever smoked the OR = 1.3 (95% CI .8-2.4) for CBD and the OR = 1.5 (95% CI .9-2.5) for BS. No association was found between CBD and duration (p = 0.3). BS increased with shorter duration <I year (7.1%), 1-4 years (5.3%), 5-14 years (5.2%), 15-24 years (2.9%) and 25+ years (2.3%) (p = .01). This study suggests that exposure and gender are associated with development of BS. Further work to better characterize parameters of exposure and individual genetic susceptibility are needed.
Beryllium-poisoning; Beryllium-disease; Beryllium-compounds; Chest-X-rays; Spirometry; Blood-sampling; Blood-analysis; Pneumoconiosis; Genes; Genetics; Genetic-factors; Respiratory-system-disorders; Pulmonary-system-disorders
Issue of Publication
Research Tools and Approaches: Exposure Assessment Methods
American Journal of Respiratory and Critical Care Medicine, 2002 International Conference, The American Thoracic Society, Atlanta Georgia, May 17-22, 2002
MI; PA; GA; WV; OH
Michigan State University
Page last reviewed: October 5, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division