NIOSHTIC-2 Publications Search

The effects of single and serial zinc oxide exposures on airway inflamation in healthy humans.

Authors
Reinties-K; Witten-A; Arjomandi-M; Balmes-J; Blanc-P; Solomon-C
Source
Am J Respir Crit Care Med 2002 Apr; 165(8)(Suppl):A46
NIOSHTIC No.
20022922
Abstract
A single exposure to zinc oxide (ZnO) results in an increase in inflammatory cells and cytokines. Serial exposures to ZnO can decrease this inflammatory response. This experiment was designed to test the hypothesis that exposure to ZnO on two consecutive occasions would decrease both the cellular and cytokine responses compared 10 one exposure. Utilizing a repeated measure, randomized, single-blind design, 6 healthy subjects (4 females; age range 26-53 yr; methacholine PC,. > 10 mg/ml) were exposed for 30 min, at rest, to: I) filtered-air (FA); 2) ZnO on one occasion (ZnO-I: conc: 10 mg/ m'); 3) ZnO on two consecutive occasions (ZnO-2: conc: 10 mg/m'). Sputum induction (3% saline, t=20 min) was performed 65 h pre- and 6 h post-exposure, Conditions were compared using the post minus pre delta value. In ZnO-I, compared to FA, there was a significant (P
Keywords
Zinc-compounds; Filters; Filtration; Sputum-analysis; Sputum-cytology; Leukocytes; Proteins; Exposure-limits; Exposure-levels
CODEN
AJCMED
CAS No.
1314-13-2
Publication Date
20020401
Document Type
Abstract
Funding Amount
929264
Funding Type
Grant
Fiscal Year
2002
Identifying No.
Grant-Number-T42-CCT-910427
Issue of Publication
8
ISSN
1073-449X
Priority Area
Research Tools and Approaches; Exposure Assessment Methods
Source Name
American Journal of Respiratory and Critical Care Medicine, 2002 International Conference, The American Thoracic Society, Atlanta Georgia, May 17-22, 2002
State
CA
Performing Organization
Center for Occupational and Enviromental Health, University of California, Berkley California
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division