Newly diagnosed chronic beryllium disease (CBD) in former beryllium workers.
Rossman-MD; Rosenman-KD; Reilly-MJ; Bush-A; Hertzberg-V; Regovich-J; Aronchick-J; Parker-J; Rice-C
Am J Respir Crit Care Med 2002 Apr; 165(8)(Suppl):A49
In a survey of two former beryllium (Be) processing plants, 1,464 individuals participated in medical screening including chest x-ray, spirometry and blood BE proliferation testing (LPT). 48 cases of definite CBD (evidence of granuloma (by biopsy) and positive Be LPT) were diagnosed. 31 (64%) of these cases were newly identified cases of CBD. All cases had complete PFTs, chest radiography, bronchoscopy, and standardized examination. The 31 newly identified cases of CBD had a mean exposure of 9.6 years and the average year of the last exposure was 1974. 16 were ever smokers and 15 never smokers. No respiratory symptoms were reported in only 6 (19%), 21 complained of cough, and 11 of shortness of breath. Chest examination was normal in 25 (81%), 3 had rales and 3 had wheezing. Chest x-rays had interstitial changes in only 10 (32%). The vital capacity was reduced (<80% of predicted) in 11, the total lung capacity was reduced in 4, the FEV1.0 was reduced in 17 (55%) and the Dlco was reduced in 15 (48%). A restrictive pattern was observed in 7 and obstructive in 8. Blood LPT to beryllium was 19.0 +-3.6 and BAL LPT to beryllium was 107.7+-21.8. Negative BAL LPT was observed in 7 (4 smokers and 3 non-smokers). These results demonstrate 64% of definite CBD was unrecognized in this population, both obstructive and restrictive patterns were seen on pulmonary function and equal numbers of smokers and non-smokers were represented.
Beryllium-compounds; Beryllium-poisoning; Beryllium-disease; Medical-research; Medical-examinations; Medical-screening; Chest-X-rays; Spirometry; Blood-samples; Blood-sampling; Blood-tests; Pulmonary-function; Smoking
Abstract; Conference/Symposia Proceedings
American Journal of Respiratory and Critical Care Medicine, 2002 International Conference, The American Thoracic Society, Atlanta Georgia, May 17-22, 2002
Michigan State University