A method to characterize aerosols produced by voluntary respiratory maneuvers.
Afshari-A; Azadi-S; Goldsmith-T; Frazer-D
Toxicologist 2002 Mar; 66(1-S):99
Many respiratory diseases are associated with changes in the composition and balance of fluids within the airways. The purpose of this study was to develop a system to measure the production of aerosols generated while performing a variety of respiratory maneuvers. Results of these measurements will be used to determine if aerosol generation is associated with airway fluid composition and the development of airway diseases. The system was designed to measure airflow, expired gas volume, and aerosols generated during a variety of ventilatory procedures. It featured a small dead space and was housed in a chamber held at body temperature to reduce the effects of evaporation and condensation. The temperature and humidity of the collected gas was recorded during the course of each experiment. Prior to each measurement, the test subject breathed HEPA filtered air for two minutes to reduce the contribution of inhaled ambient particulates. The subject then voluntarily coughed or performed an exhalation procedure into a mouthpiece attached to a spirometer. The spirometer was used to characterize the airflow pattern while collecting the exhaled air and aerosol. Three types of particle analyzers (APS, GRIMM, SMPS) were used to characterize aerosol size over a range between 10 nm and 10 m. Results show that aerosol characteristics were consistent for each test subject but varied widely between subjects. This method has potential in evaluating the toxicological effects of substances that alter airway integrity. This project is supported in part by FAA IAG 97-11.
Aerosols; Respiratory-system-disorders; Humans; Spirometry; Lung-function; Pulmonary-system-disorders
Work Environment and Workforce: Mixed Exposures; Research Tools and Approaches: Control Technology and Personal Protective Equipment
The Toxicologist. Society of Toxicology 41st Annual Meeting and ToxExpo, March 17-21, 2002, Nashville, Tennessee