Triazine is often added as a biocide/perservative to cutting fluids formulations used in the metal machine industry. Workers involved in metal machining are not only exposed to components in these cutting fluids, but biocides such as triazine which have been implicated in occupational contact irritant dermatitis (OCID). Little is known about how these cutting fluids and their ingredients influence the dermal disposition of triazine. The purpose of this study was to assess C^14 -triazine membrane transport when topically applied to inert silastic membranes and porcine skin in in vitro flow-through diffusion cell system as aqueous mineral oil (MO) or aqueous polyethylene glycol (PEG) mixtures. C14-triazine mixtures were formulated with 3 commonly used cutting fluid additives; namely, 0 or 5% linear alkylbenzene sulfonate (LAS), 0 or 5% triethanolamine (TEA), and 0 or 5% sulfurized ricinoleic acid (SRA). Triazine partitioning from the formulation into the stratum corneum (SC) was significantly reduced by LAS, while SRA significantly reduced the pH of the formulation. Triazine absorption ranged from 2.24 to 3.9% dose in porcine skin and 12.61 to 18.63% dose in silastic membranes. In silastic membranes, the complete mixture significantly reduced triazine absorption in MO-based mixtures, while in PEG-based mixtures triazine absorption and apparent permeability were significantly increased. In porcine skin, triazine permeability was significantly increased for both MO- and PEG-based complete mixtures and the trend was for greater triazine absorption in more complex PEG-based mixtures. Interestingly, SRA or TEA alone significantly reduced triazine absorption in MO-based mixtures, and this interaction appears to be more additive than synergistic. Although the physiochemical experiments suggest otherwise, triazine readily permeates a homogenous lipid membrane such as the SC, while triazine permeability and absorption was significantly enhanced by the complete mixture especially in PEG-based mixtures.
Disease and Injury: Allergic and Irritant Dermatitis
Source Name
The Toxicologist. Society of Toxicology 42nd Annual Meeting and ToxExpo, Cutting-Edge Science, Networking, New Perspectives, March 9-13, 2003, Salt Lake City, Utah
State
NC; UT
Performing Organization
North Carolina State University, Raleigh, North Carolina
Links with this icon indicate that you are leaving the CDC website.
The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website.
Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website.
You will be subject to the destination website's privacy policy when you follow the link.
CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website.
For more information on CDC's web notification policies, see Website Disclaimers.
CDC.gov Privacy Settings
We take your privacy seriously. You can review and change the way we collect information below.
These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. They help us to know which pages are the most and least popular and see how visitors move around the site. All information these cookies collect is aggregated and therefore anonymous. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance.
Cookies used to make website functionality more relevant to you. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests.
Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data.
Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. These cookies may also be used for advertising purposes by these third parties.
Thank you for taking the time to confirm your preferences. If you need to go back and make any changes, you can always do so by going to our Privacy Policy page.