Otoneurotoxic effects of solvents: review of the literature.
Demange-V; Chouaniere-D; Loquet-G; Perrin-P; Johnson-AC; Morata-T
Otorhinolaryngol Nova 2001 Jan; 11(3-4):141-150
Organic solvents are used in the industrial environment, and the combined exposure to noise and solvents (pure or in mixtures) is of concern to numerous workers from various economic sectors. Although the effects of organic solvents on the central nervous system are well known, their sensorineural effects, particularly in the auditory system, constitute a new area for research. Studies conducted with experimental animals have shown that the combined exposure to solvents and noise results in a synergistic effect on the auditory system, and that the lesions can be both cochlear and retrocochlear. In humans, there is now evidence from epidemiological studies in the occupational environment suggesting an ototoxic effect of some single solvents and solvent mixtures, as well as evidence of an interaction between noise and solvents on the auditory function. Published in French.
Ototoxicity; Neurotoxic-effects; Neurotoxicity; Solvents; Organic-solvents; Noise; Toluenes; Styrenes; Xylenes
D. Chouaniere, Department d'Epidemiologie en Entreprises, INRS, Avenue de Bourgogne, BP 27, F-54 501 Vandoeuvre-les-Nancy (France)
100-42-5; 108-88-3; 79-01-6; 1330-20-7
Neurotoxic Effects; Neurotoxic Disorders