How to Explore the Ototoxicity of Solvents in the Framework of Epidemiological Studies.
Chouaneire-D; Demange-V; Loquet-G; Perrin-P; Johnson-AC; Planeau-V; Baudin-V; Toamain-JP; Morata-T
Otorhinolaryngol Nova 2001; 11(3-4) :134-140
To study these ototoxic effects of industrial solvents in the framework of epidemiological studies, it is necessary to customize an audioiogical test battery. Such a battery must take into account the following constraints: tests must contribute to localize the lesion due to the presumed ototoxic impact; they must meet criteria expected from epidemiologic studies (reproducibility and sensitivity); and it should be possible for them to be performed in the work environment, with workers who a priori are asymptomatic. Two different audiological batteries have been developed by Swedish research groups. Both batteries use speech material that is not available in French. This report outlines the development of a test battery in French, which is comparable to the Swedish batteries, taking into consideration the pertinence and quality of tests, their feasibility, and the availability of French speech materials. The test battery proposed in this report consists of pure-tone audiometry using the Hughson Westlake technique, speech audiometry in noise as proposed Hagerman, interrupted speech audiometry with lists adapted from Fournier, stapedius reflex testing, and the distortion product otoacoustic emissions. (Full Text in French)
Ototoxicity; Solvent-vapors; Solvents; Epidemiology; Audiological-testing; Work-environment; Workers; Audiometry
D. Chouanière, Département d'Epidémiologie en Entreprises, INRS, Avenue de Bourgogne, BP 27, F-54 501 Vanduvre-lès-Nancy (France)