Effects of whole body vibration on pulmonary function in rats.
Frazer-D; McKinney-W; Stolarik-B; Reynolds-J; Rosenberry-K; Afshari-A
Biomedical engineering recent developments: proceedings of the Twenty First Southern Biomedical Engineering Conference, September 28 - 29, 2002, Bethesda, Maryland. Vossoughi J, ed. Washington, DC: Medical and Engineering Publishers, Inc., 2002 Sep; :365-366
Exposure to vibration stress occurs in numerous occupational settings (e.g. construction, agriculture, mining) where an increase in pulmonary disease has been observed. The objective of this study was to determine if vibration stress alters pulmonary function. Rats (N=10), housed in individual cylindrical chambers, received sinusoidal vibration in a horizontal plane (head to tail) for 4 hrs. at a frequency of 5 Hz and a peak acceleration of 0.75 G. Control rats (N=10) were housed in similar chambers but were not subjected to vibration. During each exposure period, animals received HEP A filtered, conditioned air. Breathing rates and PenH were measured prior to exposure, immediately following exposure, and 18 hrs. post exposure. Respiratory input impedance was measured (SCIREQ, tlexiVent) prior to and during a methacholine challenge for anesthetized animals at 18 hrs. post exposure. Although there were no significant differences in baseline respiratory input impedance, animals receiving whole body vibration were hyporesponsive to methacholine at 18 hrs. post exposure. "
In-vitro-studies; Vibration; Vibration-exposure; Pulmonary-function-tests; Pulmonary-system; Respiratory-system-disorders
Work Environment and Workforce: Mixed Exposures; Research Tools and Approaches: Exposure Assessment Methods
Biomedical engineering recent developments: proceedings of the Twenty First Southern Biomedical Engineering Conference, September 28 - 29, 2002, Bethesda, Maryland