Reduction of PAH exposure and effects in auto mechanic trainees: impact of a simple intervention evaluated by carcinogen biological monitoring.
Booth-Jones-A; Pinney-S; Goldenhar-L; Lemasters-G; Talaska-G
American Industrial Hygiene Conference and Exposition, June 1-6, 2002, San Diego, California. Fairfax, VA: American Industrial Hygiene Association, 2002 Jun; :16
We have shown previously in an animal model that prompt washing reduces the levels of adducts in skin and lung DNA of mice exposed to engine oil. We used these results to design a simple exposure intervention for a group of young auto mechanic trainees at local technical schools. The intervention consisted of a review of the animal data emphasizing the importance of proper hand washing and care. Hand cleaners (GOJO Industries, Inc. Akron, OH) were provided gratis to the participants. Hand wipes, blood and urine samples were obtained from volunteers at the time of the intervention, and at the end of the study. The levels of polycyclic aromatic compounds (PAC), leukoctye DNA adducts and 1-hydroxypyrene (1HP) were measured in the 3 matrices, respectively.
Polycyclic-aromatic-hydrocarbons; Exposure-levels; Work-environment; Workers; Animal-studies; Laboratory-animals; Blood-samples; Leukocytes
American Industrial Hygiene Conference and Exposition, June 1-6, 2002, San Diego, California
University of Cincinnati