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Comparison of human lung dosimetry models: implications for risk assessment.

Kuempel-ED; Tran-CL

Ann Occup Hyg, Inhaled Particles IX, 2002 Dec; 46(Suppl 1):337-341

http://dx.doi.org/10.1093/annhyg/46.suppl_1.337

20022229

In this study we have compared several human lung dosimetry models and predicted particle burdens in the lungs and lymph nodes of humans with working lifetime exposures to airborne particulates. The focus of this study was the clearance and retention of poorly soluble particles in the alveolar (gas exchange) region of the lungs. The models evaluated include those developed for exposure to radioactive particles and coal mine dust and a rat-based overload model extrapolated to humans. Results show that the predicted mean particle burden in the lungs varies by as much as two orders of magnitude among the different models. These findings indi- cate that risk estimates for particle-related lung diseases in humans could differ considerably depending on the choice of lung dosimetry model. Further evaluation is needed to investigate which kinetic model features best predict human lung particle burdens over a range of particle sizes, types and exposure levels and to investigate issues of variability and uncertainty.

Risk-analysis; Risk-factors; Lung-burden; Lymph-nodes; Exposure-levels; Airborne-particles; Mathematical-models; Author Keywords: dosimetry models; toxicokinetics; particles; lung burden; risk assessment

E. D. Kuempel, National Institute for Occupational Safety and Health, Risk Evaluation Branch, 4676 Columbia Parkway, M.S. C-15, Cincinnati, OH 45226-1998, USA

AOHYA3

20021201

Journal Article

ekuempel@cdc.gov

Ogden-T; Donaldson-K; Cherry-N

2003

0003-4878

EID

Research Tools and Approaches: Risk Assessment Methods

Annals of Occupational Hygiene, Inhaled Particles IX

OH