Beryllium disease natural history and exposure-response.
NIOSH 2002 Jan; :1-17
BeS progresses to CBD at a rate of 7-11 % per year. Beryllium-sensitized patients merit medical counseling and surveillance for signs of progression to disease. Medical surveillance identifies individuals with CBD of whom 22% progress to treatment with steroids. Parameters that seem to best predict progression specific to CBD are changes in forced vital capacity (FVC) over time and changes in A-a gradient with exercise. More than 50% of the beryllium machining particles in the breathing zone were less than 10 m in aerodynamic diameter. This small particle size may result in beryllium deposition into the deepest portion of the lung and may explain elevated rates of sensitization among beryllium machinists. A high percentage of the particles generated during machining are less than 0.6microm in aerodynamic diameter and from 8% to 10% of the aerosol generated may be deposited in the deep portions of the lung. Measurable beryllium contamination on workers hands and inside their vehicles indicates that take-home beryllium exposure is still a significant risk. Worker risk notification programs can positively affect workers self-protective attitudes and behaviors.
Occupational-respiratory-disease; Lung-disease; Respiratory-system-disorders; Blood-analysis; Work-environment; Genetic-factors; Lymphocytes; Bronchial-cancer; Biological-effects
National Jewish Medical and Research Center, Division of Environmental and Occupational Health Sciences, 1400 Jackson street, Denver, CO 80206
Final Cooperative Agreement Report
NTIS Accession No.
National Institute for Occupational Safety and Health
National Jewish Medical and Research Center, Division of Environmental and Occupational Health Sciences, Denver, Colorado