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Roles of glia in developmental neurotoxicity: session VI summary and research needs.
Tiffany-Castiglioni E; Guerri C; Aschner M; Matsushima GK; O'Callaghan JP; Streit WJ
Neurotoxicology 2001 Oct; 22(5):567-73
The purpose of this session was to address the molecular, pathological, and functional responses of astroglia, microglia, and oligodendroglia to neurotoxicant exposure. Neurons are the signaling cells of the nervous system, and as such are responsible for the perception of sensory stimuli and the coordination of cellular, tissue, and organismal responses to stimuli from the environment. Neuronal function and nervous tissue structure requires the participation of neuroglia, or glia, including astroglia (which participate in neurotransmitter metabolism and responses to stress and injury), radial glia and Bergmann glia (which provide scaffolding for neuronal migration during development), oligodendroglia and Schwann cells (which myelinate axons in the central and peripheral nervous systems, respectively), and microglia (which mediate inflammatory responses in the central nervous system). The roles of each of these cells as target cells and participants in various aspects of developmental neurotoxicity was discussed.
Neurotoxicity; Pathology; Nervous-system; Stimulants; Environmental-exposure; Central-nervous-system
Issue of Publication
Other Occupational Concerns; Neurotoxic Disorders
FL; NC; TX; WV
Page last reviewed: September 2, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division