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Incorporating biomarkers into 21st century risk assessments.
Maier A; DeBord DG; Savage RE
Comment Toxicol 2001 Sep; 7(5-6):519-539
In 1987, the National Research Council Board on Environmental Studies and Toxicology defined a biologic marker as any cellular or molecular indicator of toxic exposure, adverse health outcome or susceptibility. Since that time, significant advances in molecular biology and analytical chemistry have lead to the use of these biomarkers in both molecular epidemiology and toxicology studies, providing the potential to integrate the results of two disciplines, which ordinarily evaluate health outcomes at population and organism levels respectively. Tempered success in molecular epidemiology studies has evoked the call for employing biomarkers in the risk assessment process. The identification, development and validation of biomarkers for use in environmental and human health assessments have tremendous potential to improve the quality and reduce uncertainty in risk estimates. However, application of biomarker methodologies across disciplines and incorporation within risk assessment processes is inherently complex and difficult. The potential benefits of such a merger are significant. We discuss a number of issues relevant to the successful incorporation of biomarkers into the risk assessment process.
Risk-analysis; Biomarkers; Analytical-processes; Analytical-chemistry; Author Keywords: biomarkers; risk assessment
Andrew Maier, Toxicology Excellence for Risk Assessment (TERA), 1757 Chase Avenue, Cincinnati, OH 45223
Issue of Publication
Comments on Toxicology: A Journal of Critical Discussion of the Current Literature
Page last reviewed: July 16, 2021
Content source: National Institute for Occupational Safety and Health Education and Information Division