Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Antioxidant mechanisms of nitric oxide against iron-catalyzed oxidative stress in cells.

Authors
Kagan-VE; Kozlov-AV; Tyurina-YY; Shvedova-AA; Yalowich-JC
Source
Antioxid Redox Signal 2001 Apr; 3(2):189-202
NIOSHTIC No.
20021764
Abstract
Three distinct antioxidant pathways are considered through which iron-catalyzed oxidative stress may be regulated by nitric oxide (NO). The first two pathways involve direct redox interactions of NO with iron catalytic sites and represent a fast response that may be considered an emergency mechanism to protect cells from the consequences of acute and intensive oxidative stress. These are (i) NO-induced nitrosylation at heme and non-heme iron catalytic sites that is capable of directly reducing oxoferryl-associated radicals, (ii) formation of nitrosyl complexes with intracellular "loosely" bound redox-active iron, and (iii) an indirect regulatory pathway that may function as an adaptive mechanism that becomes operational upon long-term exposure of cells to NO. In the latter pathway, NO down-regulates expression of iron-containing proteins to prevent their catalytic prooxidant reactions.
Keywords
Antioxidants; Oxides; Stress; Proteins; Reaction-rates; Oxidative-processes; Iron-oxides; Exposure-levels
Contact
Dr. Valerian E. Kagan, Department of Environmental and Occupational Health, University of Pittsburgh, 260 Kappa Dr., RIDC Park, Pittsburgh, PA 15238, U.S.A.
CODEN
ARSIF2
Publication Date
20010401
Document Type
Journal Article
Email Address
kagan@pitt.edu
Fiscal Year
2001
NTIS Accession No.
NTIS Price
Issue of Publication
2
ISSN
1523-0864
NIOSH Division
HELD
Source Name
Antioxidants & Redox Signaling
State
WV; PA
TOP