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Involvement of sphingomyelinase in insulin-induced phosphatidylinositol 3-kinase activation.
Huang C; Ma WY; Ding M; Li J; Shi X; Castranova V; Vallyathan V; Bode AM; Dong Z
FASEB J 2001 Apr; 15(6):1113-1114
SPECIFIC AIM- This manuscript aims to elucidate the mechanism by which insulin activates phosphatidylinositol 3-kinase (PI-3 kinase), especially the role of sphingomyelinase (SMase) in insulin-induced PI-3 kinase activation.
Animal-studies; Laboratory-testing; Laboratory-animals; Proteins; Phosphates; Cell-growth; Author Keywords: Ceramide; Niemann-Pick disease; signal transduction
Issue of Publication
The FASEB Journal
Page last reviewed: September 2, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division