Using surveillance data as information for action, collaborative efforts in Alaska have been very successful in applying these insights toward preventing occupational mortality and serious injury. Specifically, epidemiological analysis has been effectively applied toward reducing mortality in Alaska's rapidly expanding helicopter logging industry, and it played an important supportive role in tracking the continuing progress made in reducing the mortality rate in Alaska's commercial fishing industry, as well as numerous local injury prevention efforts. Some of the methodological refinements presented here may be useful elsewhere. Layering Haddon matrices provides a useful insight for planning for injury prevention. This method should be widely applicable. The results suggest that the extension of Alaska's approach to occupational injury surveillance and prevention to other locales, and the application of these strategies to the full spectrum of occupational injury hazards, could have a broad impact on the reduction of occupational injuries.