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Cell apoptosis induced by carcinogenic metals.
Chen F; Vallyathan V; Castranova V; Shi X
Mol Cell Biochem 2001 Jun; 222(1-2):183-188
Well-documented evidence suggests that environmental and occupational exposure of toxic metals or metal-containing compounds can cause a number of human diseases, including inflammation and cancer, through DNA damage, protein modifications, or lipid peroxidation. This mini-review addresses the mechanisms of cell death induced by some carcinogenic metals, including arsenic (III), chromium (VI) and vanadium (V). A possible contribution of reactive oxygen species to metal-induced cell death is also discussed.
Carcinogens; Metals; Occupational-exposure; Environmental-exposure; Toxins; Toxic-effects; Metal-compounds; Cancer; Arsenic-compounds; Chromium-compounds; Vanadium-compounds; Author Keywords: apoptosis; metal; ROS; DNA damage; carcinogenesis
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505
7440-38-2; 7440-62-2; 7440-47-3
Issue of Publication
Molecular and Cellular Biochemistry
Page last reviewed: May 5, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division