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Carcinogenic metals and NF-kB activation.
Chen F; Ding M; Castranova V; Shi X
Mol Cell Biochem 2001 Jun; 222(1-2):159-171
Epidemiological and animal studies suggest that several metals and metal-containing compounds are potent mutagens and carcinogens. These metals include chromium, arsenic, vanadium, and nickel. During the last two decades, chemical and cellular studies have contributed enormously to our understanding of the mechanisms of metal-induced pathophysiological processes. Although each of these metals is unique in its mechanism of action, some common signaling molecules, such as reactive oxygen species (ROS), may be shared by many of these carcinogenic metals. New techniques are now available to reveal the mechanisms of carcinogenesis in precise molecular terms. In this review, we focused our attentions on metal-induced signal transduction pathways leading to the activation of NF-kappaB, a transcription factor governing the expression of most early response genes involved in a number of human diseases.
Carcinogens; Metals; Epidemiology; Animals; Animal-studies; Metal-compounds; Mutagens; Chromium-compounds; Arsenic-compounds; Vanadium-compounds; Nickel-compounds; Carcinogenicity; Carcinogenesis; Author Keywords: NF-kB; IKK; metals; signal transduction; ROS
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505
7440-38-2; 7440-62-2; 7440-47-3; 7440-02-0
Issue of Publication
Molecular and Cellular Biochemistry
Page last reviewed: May 5, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division