Intratracheal amiodarone administration to F344 rats causes acute damage to airway and parenchymal cells: the possible role of free radical generation.
Taylor-MD; Antonini-JM; Roberts-JR; Van Dyke-K; Bowman-LL; Castranova-V; Hubbs-AF; Shi-X; Leonard-SS; Reasor-MJ
Toxicologist 2001 Mar; 60(1):424
Intratracheal (i.t) instillation of the antiarrhythmic drug amiodarone (AD) leads to lung damage, inflammation, and fibrosis in F344 rats. To assess the direct effect of AD in this damage, male F344 rats were instilled with 6.25 mg/kg AD (3.125 mg/ml solution in sterile water) or the sterile water vehicle and subjected to bronchoalveolar lavage (BAL) at 15 min, 1 hr, and 3hr following i.t. treatment. The blood protein albumin was markedly elevated in the first BAL fraction of AD-treated animals at these time points, indicating an early damage to the alveolar-capillary barrier.
Lung; Fibrosis; Proteins; Animal-studies; Laboratory-animals; Laboratory-testing
The Toxicologist. Society of Toxicology 40th Annual Meeting, March 25-29, 2001, San Francisco, California