Obesity is a major risk factor associated with a variety of human disorders. While its involvement in disorders such as diabetes, coronary heart disease and cancer have been well characterized; it remains to be determined if obesity has a detrimental effect on the nervous system. Due to the limited regenerative capability of the CNS and the specific vulnerability of certain cell types to disease and chemical injury, obesity may confer an added risk of damage to the brain as it does to other organ systems. To address this possibility we sought to determine whether obesity can mediate/modify the brain's response to neurotoxic insult.
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