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Obesity as a potential risk factor for dopaminergic neurotoxicity.

Authors
Sriram K; O'Callaghan JP
Source
Neurotoxicology 2001 Dec; 22(6):888
Link
https://www.sciencedirect.com/science/article/pii/S0161813X01000791/pdfft?md5=eeec4203587e469e580c747b00e8e7f1&pid=1-s2.0-S0161813X01000791-main.pdf
NIOSHTIC No.
20021456
Abstract
Obesity is a major risk factor associated with a variety of human disorders. While its involvement in disorders such as diabetes, coronary heart disease and cancer have been well characterized; it remains to be determined if obesity has a detrimental effect on the nervous system. Due to the limited regenerative capability of the CNS and the specific vulnerability of certain cell types to disease and chemical injury, obesity may confer an added risk of damage to the brain as it does to other organ systems. To address this possibility we sought to determine whether obesity can mediate/modify the brain's response to neurotoxic insult.
Keywords
Risk-factors; Risk-analysis; Neurotoxicity; Central-nervous-system-disorders; Nervous-system-disorders; Neurotoxic-effects; Laboratory-animals; Animals; Animal-studies; Toxic-effects
CODEN
NRTXDN
Publication Date
20011201
Document Type
Abstract
Fiscal Year
2002
Issue of Publication
6
ISSN
0161-813X
NIOSH Division
HELD
Source Name
Neurotoxicology
State
WV
Page last reviewed: May 5, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division