Enhanced oxidative stress in the skin of vitamin E-deficient mice exposed to metal working fluid.
Smith C; Kisin E; Murray A; Castranova V; Kommineni C; Shvedova AA
Toxicologist 2001 Mar; 60(1):60
Metal working fluids (MWFs) are widely used in industry for metal cutting, drillings, shaping, lubricating, and milling. Many occupational health concerns have arisen for workers exposed to MWFs. It has been reported earlier that occupational exposure to MWFs causes allergic and irritant contact dermatitis. Previously, we have shown that dermal exposure of female and male B6C3F1 mice to 5% MWFs for three months resulted in accumulation of mast cells and elevation of histamine in the skin. Topical exposure to MWFs also resulted in elevated oxidative stress in the liver of both sexes and the testes in males. The goal of this study was to evaluate whether oxidative stress in the skin exacerbated mast cell influx after MWF treatment. Oxidative stress in skin of B6C3F1 mice was generated by vitamin E deprivation. Mice were given vitamin E deficient or basil diets for 34 weeks.
Metalworking-fluids; Metals; Occupational-hazards; Occupational-health; Occupational-exposure; Dermatitis
The Toxicologist. Society of Toxicology 40th Annual Meeting, March 25-29, 2001, San Francisco, California