Reactive Oxygen Species and Silica-induced Carcinogenesis.
Shi-X; Ding-M; Chen-F; Vallyathan-V; Castranova-V
Environmental Stressors in Health and Disease 2001; Vol. 1:203-224
Epidemiological and pathological studies have established that occupational exposure to crytalline silica leads to the development of pulmonary fibrosis (1,2). Increasing evidence from epidemiological and animal studies has also implicated crystalline silica as a potential carcinogen (3,4) (e.g., inhalation of silica has been shown to be carcinogenic in rats) (5-9). Intrapleural administration of crytalline silica in rats leads to the induction of localized malignant histiocytic lymphomas. Epidemiological studies also show that there appears to be an increased lung cancer risk in many, but not all, human subjects with silicosis (4,9). Based on current evidence obtained from studies on laboratory animals and epidemiological studies on humans, the International Agency for Reseearch on Cancer has classified crytalline silica as a human class I carcinogen (9).
Silicates; Carcinogenesis; Epidemiology; Pathology; Occupational-exposure; Pulmonary-system-disorders; Fibrosis
Book or book chapter
Other Occupational Concerns; Pulmonary System Disorders
Environmental Stressors in Health and Disease Volume 1