Neurochemical correlates of cognitive deficits in weanling rats exposed to chlorpyrifos.
Schuh-RA; Carter-JC; O'Callaghan-JP; Jett-DA
Toxicologist 2001 Mar; 60(1):241
Previous studies have shown that moderate to high levels of chlorpyrifos (CPF) alter cognitive function in adult and immature rats, probably related to the inhibition of acetylcholinesterase (AChe). We have previously reported on an alteration of cAMP signaling by CPF in rats exposed to moderate doses, and PC12 cells exposed to CPF at doses lower than those required to inhibit AChE. In the present study, we tested the hypothesis that the exposure to CPF during brain development causes deficits in cognitive function of weanling rats, and we determined the relationship between cognitive effects, AChE activity, muscarinic receptor binding, and the expression of the phosphorylated form of Ca2+/cAMP-dependent response element binding protein (pCREB).
Animal-studies; Laboratory-animals; Exposure-levels; Exposure-methods; Cell-cultures; Proteins
The Toxicologist. Society of Toxicology 40th Annual Meeting, March 25-29, 2001, San Francisco, California