Role of polychlorinated biphenyl exposure in the progression of neoplasia.
Authors
Sargent LM
Source
PCBs. LW Robertson and LG Handsen, eds., Lexington, KY: The University of Kentucky Press, 2001 Jan; :373-379
Link
NIOSHTIC No.
20021431
Abstract
Progression is the conversion of initiated and promoted cells into cancer cells. This stage of neoplasia is characterized by an increased growth rate, metastasis, aneuploidy and evolving karyoptic instability. The stage of progression has been examined in experimental models of skin and liver cancer. Early experiments of multistage epidermal carcinogenesis demonstrated that neoplasms occur at a high frequency when complete carcinogens are applied chronically (Shubik et al., 1950). In the skin model, it was demonstrated that chronic application of an initiator to mouse skin shortened the latency to neoplasia (Roe et al., 1972; Hennings, et al., 1985). The stage of progression in liver cancer has been examined by an initiation-promotion-initiation protocol (IPI) that was first suggested by Potter (1981) and later demonstrated experimentally by Scherer (1984). In the rat liver model, the transition from preneoplastic to tumor is characterized by the appearance of foci in foci, increated chromosome damage (Pitot et al., 1989, Pitot, et al., 1991; Dragan et al., 1993; Sargent et al., 1996), and increased incidence of carcinomas (Scherer, et al., 1984; Reddy, et al., 1982).
Links with this icon indicate that you are leaving the CDC website.
The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website.
Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website.
You will be subject to the destination website's privacy policy when you follow the link.
CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website.
For more information on CDC's web notification policies, see Website Disclaimers.
CDC.gov Privacy Settings
We take your privacy seriously. You can review and change the way we collect information below.
These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. They help us to know which pages are the most and least popular and see how visitors move around the site. All information these cookies collect is aggregated and therefore anonymous. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance.
Cookies used to make website functionality more relevant to you. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests.
Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data.
Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. These cookies may also be used for advertising purposes by these third parties.
Thank you for taking the time to confirm your preferences. If you need to go back and make any changes, you can always do so by going to our Privacy Policy page.