Auditory function after single or combined exposure to styrene: a review.
Morata TC; Campo P
Noise Induced Hearing Loss: Basic Mechanisms, Prevention and Control. London: NRN Publications, 2001 Jan; :293-304
Styrene is a widely used organic solvent, heavily employed in many manufacturing industries, as well as in other economic sectors. Recently, evidence is beginning to accumulate on the deleterious effects that styrene exposures have on the auditory system. In rats, a well-suited metabolic animal model for these studies, aromatic solvents such as styrene have been shown to affect the auditory sensitivity mainly in the mid-frequency range. Outer hair cells are the primary targets within the organ of Corti, although the spiral ganglions are not spared. Therefore, styrene must be considered as an ototoxic chemical agent that can be potentially neurotoxic. Finally, noise-styrene exposures can have synergistic effects on the auditory system. The findings reported in both human and animal studies indicate that exposures to styrene, or to styrene associated to noise, may dramatically impact occupational hearing conservation practices and legislation. Both human and animal studies will be summarized in discussing the effects of styrene alone or in combination with noise. Gaps in scientific knowledge are highlighted to assist in future research.
Auditory system; Styrenes; Organic solvents; Noise; Exposure levels; Synergism; Hearing loss; Neurotoxicity; Neurotoxic effects; Hearing impairment; Hearing level; Hearing loss
Book or book chapter
Henderson D; Prasher D; Kopke R; Salvi R; Hamernik R
Noise Induced Hearing Loss: Basic Mechanisms, Prevention and Control