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Gene environment interactions and exposure to JP-8 jet fuel.
Butler-MA; Flugel-CA; Krieg-EF Jr.; Snawder-JE; Kesner-JS
JP8: Final Risk Assessment. Kendall RK, Smith E, eds. Brooks City-Base, TX: Air Force Institute for Operational Health, 2001 Aug; :76-80
Final analysis of gene-environment interactions in the JP8 jet fuel study will be completed as soon as data are available on all outcome measures. Analysis will be simplified because results of the genotype analysis in the 316 participants have shown that there is no significant difference in distribution of genotypes across exposure categories. Exposure will be refined by including measures of dermal exposure and blood levels of JP8 jet fuel components. Gene environment interactions will be examined in the postural sway test, an assessment of a participant's control mechanism for governing balance and in the conditional eyeblink response, which can identify cognitive deficits. In addition, gene interactions will be evaluated in the GASH/BARS system that is designed to measure motivation, response speed, coordination, grip strength, complex mental functioning, memory, and attention. Furthermore, interactions with passive benzene and naphthalene exposure, exhaled and urinary benzene and naphthalene, and molecular adducts of naphthalene may be described.
Jet engine fuels; Air force personnel; Exposure; Physiology; JP-8; Jet propellant type 8; Genes; Genetics
Book or book chapter
NTIS Accession No.
JP8: Final Risk Assessment
Page last reviewed: May 5, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division