Use of an existing database to evaluate lung cancer risk and silica exposure in Vermont granite workers.
Arbete och Halsa 2001 Jun; 2001(10):341-343
Introduction: Vermont granite workers are known to have experienced high past exposures to silica dust. Since most have had little other occupational exposure, they are, therefore, a very suitable group for study of lung cancer and silica exposure. Previous studies have provided evidence of excess lung cancer mortality among the higher and longer exposed granite workers, particularly longer-tenured workers in the sheds. These studies have been handicapped, however, through restriction of the analysis to job and tenure surrogates, with the resulting potential for misclassification and inability to evaluate quantitative exposure-response. The omission was not through lack of environmental exposure data. From 1924 to 1977 six environmental surveys were undertaken in Vermont granite sheds and quarries, resulting in an extensive database of industrial hygiene information, which has also already been summarized (2). To remedy this omission, therefore, the mortality follow-up data for the Vermont cohort has been analyzed in conjunction with dust concentration data from these sources, incorporating job histories available in the cohort to provide cumulative respirable silica exposures.
Respiratory-system-disorders; Pulmonary-system-disorders; Lung-cancer; Lung-disease; Cancer; Risk-analysis; Exposure-assessment; Silica-dusts; Employee-exposure; Information-retrieval-systems; Mortality-data; Mortality-rates; Job-analysis; Quarries; Quarry-workers; Quartz-dust; Respirable-dust; Environmental-exposure; Epidemiology
M. D. Attfield, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health CDC, Morgantown, WV, USA
Hagsberg-M; Knave-B; Lillienberg-L; Westberg-H
Arbete och Halsa (X2001 - exposure assessment in epidemiology and practice, June 10-13, 2001, Göteborg, Sweden)