Serum organochlorine levels and breast cancer: a nested case-control study of Norwegian women.
Ward EM; Schulte PA; Grajewski B; Anderson A; Patterson DG; Turner W; Jellum E; Deddens JA; Friedland J; Roeleveld N; Waters M; Butler MA
Am J Epi 2000 Jun; 151(11)(Suppl):S1
This study investigated the potential association between organochlorine exposure and breast cancer, utilizing stored sera collected in 1973-1991 from the Janus serum bank in Norway. Breast cancer cases were ascertained prospectively from among 25,431 female serum bank donors. A total of 150 controls were matched to cases by dates of sample collection and birth. One gram of serum from subject was analyzed for a total of 71 organochlorine compounds. Six pesticides (B-HCCH, heptachlor epoxide, oxychlordane, trans-nonachlor, DOE, and p,p'-DDT) and 26 individual PCB congeners had >90% of samples over the limit of detection. There was no evidence for higher mean serum levels among cases for any of these compounds, or any trend of increasing risk associated with higher quartiles of exposure. The remaining compounds (including dieldrin) were analyzed with respect to proportion of cases and controls having detectable levels. Our study did not confirm the recent findings of a Danish study of increased concentrations of dieldrin in serum of breast cancer cases. The evidence to date on the association between serum organochlorines is not entirely consistent, but there is accumulating evidence that serum levels of DOE and total PCBs are not important predictors for breast cancer in the general population. Studies to date have not been able to evaluate whether exposure to highly estrogenic, short- lived PCB congeners increases breast cancer risk, nor have they fully evaluated the risk associated with organochlorine exposure in susceptible subgroups or at levels above general population exposure, including women with occupational exposure.
Organo-chlorine-compounds; Breast cancer; Women; Pesticides; Pesticide residues; Serology; Epidemiology; Statistical analysis
DART; DSHEFS; EID
American Journal of Epidemiology, Abstracts of the 33rd Annual Meeting of the Society for Epidemiologic Research, Seattle, Washington, June 15-17, 2000