Effects of thyroid status on lung damage and activities of lung phagocytes under basal conditions and following LPS exposure.
Huffman LJ; Judy DJ; Rao KMK; Frazer DG; Goldsmith WT
FASEB J 2000 Mar; 14(4):A190
The objectives of this investigation were to study the effects of hypo- and hyperthyroidism on lung cell damage and the activity of lung phagocytes under basal conditions and during inflammatory responses induced by exposure to lipopolysaccharide (LPS). Thyroid status is adult male rats was altered by thyroidectomy or thyroxine injections for 15 days. Rats were studied 18 h after inhalation exposures to air or to LPS (100 ug/ml; 3 h). In a hyperthyroid state alone, there was a greater degree of lung cell damage and alveolar-capillary barrier disruption, an incre3ase in the number of phagocytes which could be harvested from the lungs by bronchoalveolar lavage, and an increase in nitric oxide production by lung phagocytes. On the other hand, hypothyroidism alone was associated with opposite effects. Similar effects of thyroid status on lung cell damage and lung phagocytes were also observed following inhalation exposures to LPS. These results suggest that thyroid status can modulate the overall state of oxidant balance in mature lungs and that increased thyroid hormone levels are associated with pro-oxidant pulmonary effects. As a consequence of this, lung inflammatory reactions to LPS appear to be relatively more pronounced in a hyperthyroid state and less pronounced in a hypothyroid state.
Thyroid gland disorders; Thyroid gland; Lung disorders; Phagocytes; Cell damage; Exposure levels; Respiratory system disorders; Pulmonary system disorders; Laboratory animals; Animals; Animal studies; Inhalation studies; Exposure assessment
Abstract; Conference/Symposia Proceedings
The FASEB Journal. Experimental Biology 2000, San Diego, California, April 15-18, 2000