Can gas trapping at low lung volumes reduce total lung capacity?
Frazer DG; McKinney WG; Friend KA; Tomblyn S
Proceedings of the 19th Southern Biomedical Engineering Conference, Center for Biomedical Engineering, Virginia Tech, Blacksburg, Virginia, April 14-16, 2000. Arlington, VA: National Science Foundation, 2000 Apr; :44
In the past we have examined many characteristics of the mechanism responsible for gas trapping in excised lungs [1,2]. Even though there is evidence that gas is trapped during lung inflation  and remains trapped at maximum lung volume , the effects of gas trapping on the mechanical properties of the lung during expansion are not well understood. The objective of this study was to determine how gas trapped in the lung at low lung volumes 'affects lung expansion by answering the question. "Does" trapped gas aid in holding the lung open by interdependent forces, or does the trapped gas interfere with lung expansion?" In the first case, trapped gas would be expected to reduce the energy required to expand the lung while, in the second case, more energy would be required for lung expansion.
Gases; Laboratory animals; Animals; Animal studies; Lung; Lung function; Models
HELD, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505
Proceedings of the 19th Southern Biomedical Engineering Conference, Center for Biomedical Engineering, Virginia Tech, Blacksburg, Virginia, April 14-16, 2000