Mechanisms of arsenic carcinogenicity: genetic or epigenetic mechanisms?
J Environ Pathol Toxicol Oncol 2000 Jul-Sep; 19(3):281-286
Environmental and occupational exposure to arsenic is associated with increased risk of skin, urinary bladder, and respiratory tract cancers. The mechanisms responsible for arsenic carcinogenesis have not been established. Arsenic does not act through classic genotoxic and mutagenic mechanisms, as do other metals such as cadmium or chromium. Increasing evidence indicates that arsenic acts at the level of tumor promotion by modulating the signaling pathways responsible for cell growth.
Arsenic-compounds; Arsenates; Carcinogenesis; Carcinogenicity; Carcinogens; Occupational-exposure; Environmental-exposure; Skin-cancer; Respiratory-system-disorders; Bladder-cancer; Risk-factors; Risk-analysis; Cell-growth; Genes
Petia P. Simeonova, NIOSH, HELD, TMBB, 1095 Willowdale Road, Mailstop 3014, Morgantown, WV 26505-2888
Journal of Environmental Pathology, Toxicology, and Oncology