A retrospective job exposure matrix for estimating exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Piacitelli L; Marlow D; Fingerhut M; Steenland K; Sweeney MH
Am J Ind Med 2000 Jul; 38(1):28-39
A job exposure matrix was developed to estimate the 2,3, 7,8-tetrachlorodibenzo-p-dioxin exposure of 3,538 workers who produced 2,4,5-trichlorophenol and its derivatives. Daily TCDD exposure scores that were plant, process, and period specific were estimated for each job title as the product of 1) the concentration of TCDD (microg/g); 2) a qualitative factor to account for the extent of worker contact and 3) time exposed to TCDD contamination. Daily scores were summed to compute individual cumulative TCDD exposure scores. Daily TCDD exposure scores ranged from 0.001 to 1,250. Cumulative TCDD scores ranged from 0.002 to 1,559,430. The 393 workers with records of chloracne in the TCDD exposure cohort (11%) had markedly higher cumulative scores than those with no record of chloracne (a median score of 11,546 vs. 77). The cumulative TCDD exposure scores incorporate both duration and level of exposure, and permit the relative ranking of worker exposures for the evaluation of exposure-response relationships between TCDD exposure and mortality in an updated cohort study analysis.
Risk analysis; Dioxins; Humans; Skin disorders; Skin lesions; Dose response; Chlorinated hydrocarbons; Environmental contamination; Chemical manufacturing industry; Chemical industry workers; Workplace studies;
Author Keywords: dioxin; TCDD; exposure assessment; Agent Orange; 2,4,5-trichlorophenol; phenoxy herbicides
Laurie Piacitelli, NIOSH, 4676 Columbia Parkway, MS R14, Cincinnati, OH 45226
DSHEFS; EID; OD; DART
American Journal of Industrial Medicine