Prioritization of NTP reproductive toxicants for field studies.
Moorman WJ; Ahlers HW; Chapin RE; Daston GP; Foster PMD; Kavlock RJ; Morawetz JS; Schnorr TM; Schrader SM
Reprod Toxicol 2000 Jul-Aug; 14(4):293-301
Population studies that evaluate human reproductive impairment are time consuming, expensive, logistically difficult, and with limited resources must be prioritized to effectively prevent the adverse health effects in humans. Interactions among health scientists, unions, and industry can serve to identify populations exposed to potential hazards and develop strategies to evaluate and apply appropriate controls. This report describes a systematic method for prioritizing chemicals that may need human reproductive health field studies. Rodent reproductive toxicants identified from the National Toxicology Program (NTP) Reproductive Assessment by Continuous Breeding (RACB) protocol were prioritized on the basis of potency of toxic effect and population at risk. This model for prioritization links NTP findings with data from the National Occupational Exposure Survey (NOES) and the Hazardous Substance Data Base (HSDB) or the High Production Volume Chemical Database (HPVC) to prioritize chemicals for their potential impact on worker populations. The chemicals with the highest priority for field study were: dibutyl phthalate, boric acid, tricresyl phosphate, and N,N-dimethylformamide.
Reproductive system; Reproductive hazards; Reproduction; Reproductive effects; Reproductive system disorders; Chemical analysis;
Author Keywords: Prioritization; Reproductive toxicants; NTP; RACB; NOES; HSDB
National Institute for Occupational Safety and Health (NIOSH), 4676 Columbia Pkwy, Cincinnati OH, 45226, USA
DART; EID; DSHEFS