Hexavalent chromium Cr(VI) is a human carcinogen that may be present in the workplace air of a variety of occupational settings. Occupational exposure to Cr(VI) has been associated with a number of work activities, including metal plating, welding, spray painting, tanning and abrasive blasting operations. Recent efforts in the authors laboratory have been directed toward the development and evaluation of field-porable methods for the on-site measurement of Cr(VI) and other toxic metals in workplace air and other environmental matrices. Various analytical methods are in existence for the determination of airborne Cr(VI) in fixed-site laboratories with conventional laboratory instrumentation, but reliable field-portable methods are needed for on-site occupational monitoring of this species. Field-portable methods are often desired so that decisions regarding worker protection, engineering controls, etc., can be made quickly. The capability for rapid decision making based on field analysis results can help to save costs, and also offers a means to assess (and thereby) prevent worker overexposures to hexavalent chromium in a timely manner.