The role of tumor necrosis factor alpha in chemical-induced hepatotoxicity.
Luster MI; Simeonova PP; Gallucci RM; Bruccoleri A; Blazka ME; Yucesoy B; Matheson JM
Ann NY Acad Sci 2000 Sep; 919:214-220
Only recently have toxicologists come to understand the role of inflammation, and TNFalpha specifically, in classical toxicological processes. This relationship appears fairly complex, as inflammation and proliferation may well be only one facet of a time- and dose-dependent continuum of toxicological and repair processes. Not surprisingly, considerable efforts are being undertaken using our newly found understanding of molecular control to develop specific and safe chemical, biological, and molecular regulators of TNFalpha for potential therapeutic use. Their effectiveness in controlling environmental or occupational diseases has yet to be established.
Hepatotoxicity; Hepatotoxins; Hepatocytes; Toxicology; Occupational diseases; Environmental hazards; Environmental health
Annals of the New York Academy of Sciences