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Reactive oxygen species in the aerobic decomposition of sodium hydroxymethanesulfinate.

Authors
Makarov SV; Mundoma C; Svarovsky SA; Shi X; Gannett PM; Simoyi RH
Source
Arch Biochem Biophys 1999 Jul; 367(2):289-296
NIOSHTIC No.
20000968
Abstract
Sodium hydroxymethanesulfinate, (HOCH2SO2Na, HMS) is relatively stable in aqueous alkaline environments, but rapidly decomposes in acidic medium to give a variety of products that include sulfur dioxide. A detailed kinetic and mechanistic study of the decomposition of HMS in slightly acidic medium has shown a process that produces dithionite, S2O2-4, which is preceded by an induction period which persists for as long as molecular oxygen is present in the reaction solution. The complete consumption of molecular oxygen is a prerequisite for the formation of S2O2-4. Among some of the intermediates detected in the decomposition of HMS is the sulfite radical, SO-3. Comparisons are made between the decomposition mechanisms of thiourea dioxide (aminoiminomethanesulfinic acid) and HMS.
Keywords
Thioureas; Acidity; Sulfur-compounds; Tumorigenesis; Toxicopathology; Author Keywords: hydroxymethanesulfinate; thioureas oxides; aminoiminomethanesulfinic acid; sulfoxylate ion; sulfur dioxide radical ion; sulfite radical ion; reactive oxygen species
CODEN
ABBIA4
Publication Date
19990715
Document Type
Journal Article
Fiscal Year
1999
Issue of Publication
2
ISSN
0003-9861
NIOSH Division
HELD
Priority Area
Cancer Research Methods
Source Name
Archives of Biochemistry and Biophysics
State
WV
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