Occupational health: recognizing and preventing work-related disease and injury, 4th edition. BS Levy, and DH Wegman, eds. Philadelphia, PA: Lippincott Williams and Wilkins, 2000 Jan; :447-458
Since the 1970s, office workers worldwide have frequently complained of mucus membrane irritation, fatigue, and headache when working in specific buildings, with improvements within minutes to an hour of leaving the building. This constellation of symptoms, with tight temporal association to building occupancy, is call sick building syndrome. It is the most frequent of building-associated health complaints in industrialized countries, which also include diseases caused by infection, hypersensitivity, and specific toxins. Researchers have estimated that as many and 30% of office workers report symptoms attributed to poor air quality, and workers in buildings not known to have indoor air-quality problems have many complaints attributed to the indoor work environment.
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