Role of sensitization routes in the development of type I hypersensitivity to natural rubber latex in mice.
Woolhiser-MR; Munson-AE; Meade-BJ
Am J Ind Med 1999 Sep; 36(S1):139-141
These experiments suggest that mouse can serve as an acceptable test system to mimic human latex exposure as mice exposed to latex proteins subcutaneously, intranasally and topically all demonstrated specific IgE responses. The increase in latex specific IgE following topical application of latex proteins suggests that human dermal exposure to products such as latex gloves has the potential to contribute to latex sensitization. Although preliminary immunoblots from s.c. and topically exposed mice show similar profiles, a number of bands appear to be unique, thereby supporting the possibility that different routes of human exposure may lead to the varied allergen-specific IgE profiles observed in health care workers and spina bifida patients. these models will be beneficial ion testing intervention strategies designed to prevent NRL hypersensitivity.
Work-environment; Dermatitis; Allergic-dermatitis; Allergens; Hypersensitivity; Health-care-personnel; Animal-studies; Sensitization; Laboratory-animals; Animals;
Author Keywords: latex; hypersensitivity; allergy; IgE; mouse; occupational health and safety; work environment
Michael R. Woolhiser, National Institute for Occupational Safety and Health, 1095 Willowdale Road MS 2015, Morgantown, WV 26505
American Journal of Industrial Medicine