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Carcinogenic potential of condensed pyrolysis effluents from iron foundry casting operations, final report, volumes I-V.
Shellenberger-TE; Garner-FM; Plankenhorn-LJ
NIOSH 1984 Oct; :1-850
This five volume set describes a study of carcinogenesis bioassay of condensed pyrolysis effluents from iron foundry casting operations using hamsters. In that study, Syrian-golden-hamsters were administered effluents from shell sand, green sand, furan (110009), or urethane (51796) casting molds by intratracheal instillation once a week for 18 weeks. The concentrations were 5 or 10 milligrams (mg) effluent in 0.2 milliliter distilled water, except for effluents from the urethane mold which were administered in amounts of 2.5 or 5.0mg. The animals were maintained until 98 percent mortality occurred or until week 103 or 117. Volume I explores the numbers of respiratory tract tumors, condcluding that foundry mold effluents are not carcinogenic in hamsters at the concentrations used. Volume II presents data tabulations for a carcinogenic bioassay of condensed effluents obtained from iron foundry casting operations that used hamsters as the test species. The tables include sample collected rate, pH of collected samples, solubility of foundry samples in water and cyclohexane, and the elemental composition of furan, urethane, shell sand, and green sand effluents. Cumulative hamster mortality and survival data are presented. umulative mortality and body weight changes during the acute study are presented. Photographs and diagrams of the samplers and sampling trains are also presented. Volume III presents data tabulations for a carcinogenesis bioassay of condensed effluents obtained from iron foundry casting operations that used hamsters as the test species. Gross pathological observations of various organs are summarized, lesions observed in respiratory tract tissue masses in males and females are tabulated. Volume IV calculates an individual mortality inventory for each animal. Data for a survival analysis using the Kaplan Meier product limit method was tabulated. Data tables of individual and mean body weights of males for weeks 1 through 111 and females for weeks 11 through 102 were prepared. ata for the statistical analysis of body weight changes of males and females were also tabulated. Volume V tabulates the histopathological results for each individual animal and constructs a tumor inventory for each animal.
Cancer; Iron; Foundries; Respiratory-disorders; Pyrolysis; Casting; Vapors; Gases; Pulmonary-disorders; Lungs; Pathology
51-79-6; 50-32-8; 1309-37-1; 110-00-9
Final Contract Report
NTIS Accession No.
National Institute for Occupational Safety and Health
Borriston-Laboratories Inc., Temple Hills, MD
Page last reviewed: September 2, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division