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Chronic inhalation toxicology study in monkeys and rats exposed to fibrous glass, volume 2, appendices.
Mitchell RI; Reif RB; Mosberg AT; Thake DC; Connell MM
NIOSH 1982 Oct; :1-542
Data accompanying a chronic toxicity study of fiber glass in monkeys and rats is presented. The protocol and standard operating procedures of the project are given. The methodology for determining clinical chemistry and hematology parameters was presented. Daily concentrations of fiber glass concentrations in the exposure chamber are tabulated. Data used in determining the precision of light, medium, and heavy filter weights is noted. Inertial characteristics of fibers are discussed. Mean weekly body weights of the experimental animals are tabulated. Data analyses of the survival of the experimental animals are given. Coded and tabulated pathology reports for each experimental animal are presented. Particle size distribution data of glass fibers determined from filter samples in the exposure chambers are provided. Procedures for determining the size characteristics of glass fibers deposited in monkey and rat lungs are noted. Three dimensional plots of glass fiber particle size distributions in monkey and rat lungs are presented. Calculated values of the lung burden of glass fibers in rats and monkeys are listed.
Fibrous-glass; Respiratory-system-disorders; Toxicology; Fiber-deposition; Dermatitis
Final Contract Report
NTIS Accession No.
National Institute for Occupational Safety and Health
Battelle Columbus Labs., Columbus, OH
Page last reviewed: July 23, 2021
Content source: National Institute for Occupational Safety and Health Education and Information Division