New method for occupational cancer surveillance.
NIOSH 1993 Jan; :1-10
Biomarkers of response to exposure to occupational carcinogens may allow early detection of those individuals at risk for the development of occupational cancers. Since many occupational carcinogens appear to have an effect on oncogene activation in vitro, the detection of oncogene activation by assaying for the expression of oncogene encoded proteins in vivo via the detection of these proteins in serum may be useful biomarker of response to exposure to occupational carcinogens. A serum immunoblotting assay based on monoclonal antibodies to oncogene protein sequences was used to investigate serum oncogene protein expression in cancer patients versus normal controls and in cohorts exposed to occupational carcinogens. Results in cancer patients indicate that this approach can be used to distinguish a percentage of individuals with common cancers from controls, and that these changes may be detectable early in the disease process at the level of pre-malignant lesions. Results in occupational cohorts exposed to carcinogens indicate that his approach can be used to distinguish a percentage of those individuals who subsequently develop cancer (39% of those who develop cancer were positive compared to 7% of those who did not develop cancer), and the average lead time between serum detection and clinical diagnosis was 16 months. These results suggest that immunoblotting detection of serum oncogene encoded proteins may be useful biomarkers of response for the early identification of workers at risk for the development of cancer due to their occupational carcinogen exposures.
Carcinogens; Occupational-exposure; Methodology; Literature-review; Neoplastic-disease; Asbestos; Silica; Pulmonary-fibrotic-disease; Disease-prevention
Columbia University, School of Public Health, Division of Environmental Sciences, 60 Haven Avenue, B-1 Level, New York, New York 10032, USA
Final Grant Report
NTIS Accession No.
National Institute for Occupational Safety and Health
Columbia University, School of Public Health, Division of Environmental Sciences