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Current intelligence bulletin 21 - trimellitic anhydride (TMA).
Morgantown, WV: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 78-121, (CIB-21), 1978 Feb; :1-8
The National Institute for Occupational Safety and Health (NIOSH) recommends that trimellitic anhydride (TMA) be handled as an extremely toxic agent in the workplace. Exposure to this compound may result in noncardiac pulmonary edema (apparently without benefit of a pulmonary irritation warning), immunological sensitization, and irritation of the pulmonary tract, eyes, nose, and skin. There is no current Occupational Safety and Health Administration (OSHA) exposure standard for trimellitic anhydride. The Amoco Chemicals Corporation, the sole domestic producer, suggests a limit of "0.05 mg/m3 or less for susceptible individuals."(1) NIOSH has prepared this Current Intelligence Bulletin to advise you of recent findings of toxic effects of trimellitic anhydride and to provide some precautions for handling trimellitic anhydride in the workplace. Attached are "Suggested Procedures for Minimizing Employees' Exposure to Trimellitic Anhydride."
Industrial-medicine; Exposure-levels; Toxicology; Pulmonary-edema; Curing-agents; Anhydrides; Toxic-materials; Occupational-safety; Health-hazards
Numbered Publication; Current Intelligence Bulletin
NTIS Accession No.
DHEW (NIOSH) Publication No. 78-121; CIB-21
National Institute for Occupational Safety and Health
Page last reviewed: September 2, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division