Current intelligence bulletin 28 - vinyl halides carcinogenicity.
NIOSH 1978 Sep; :1-12
The National Institute for Occupational Safety and Health (NIOSH) and the Occupational Safety and Health Administration (OSHA) jointly recommend that vinyl bromide and vinylidene chloride be considered in the workplace as potential carcinogens to humans and controlled with the same degree of prudence as vinyl chloride, another vinyl halide currently regulated as a carcinogen by OSHA. This recommendation is based on the results of recent studies indicating that exposure to vinyl bromide and to vinylidene chloride causes angiosarcoma of the liver and other cancers in laboratory animals. Safe levels of exposure to carcinogens have not been demonstrated, but lowered exposure to carcinogens may in general decrease the probability of cancer development. Vinyl chloride is known to cause angiosarcoma of the liver and cancers of other sites in laboratory animals and in humans. At this time, adequate carcinogenicity studies of vinyl bromide and vinylidene chloride have been conducted only in laboratory animals. In view of the present state of knowledge in carcinogenesis, substances that cause cancer in laboratory animals are considered a potential cancer risk to humans. Vinyl chloride is the only vinyl halide for which an OSHA exposure standard currently exists. In light of the recent laboratory animal studies demonstrating carcinogenicity of vinyl bromide and vinylidene chloride, NIOSH and OSHA have jointly prepared this Current Intelligence Bulletin. Its purpose is to advise the occupational health community of the pertinent data and complications for exposed workers. NIOSH and OSHA request that producers, distributors professional associations, and unions transmit the information in this Bulletin to their customers, employees, associates, and members.
Exposure-levels; Toxic-materials; Occupational-safety-programs; Carcinogens; Hazardous-materials; Laboratory-animals; Mutagens; Plastics-industry
75-01-4; 593-60-2; 75-35-4
Numbered Publication; Current Intelligence Bulletin
NTIS Accession No.
DHEW (NIOSH) Publication No. 79-102; CIB 28
National Institute for Occupational Safety and Health